Over the last decade, industry’s productivity has been declining with rising R&D costs and time taken to reach market. Medicinal chemistry is defined as a focused science that is developed to cover a wide range of fields related with identification, synthesis and drug development for therapeutic applications. This science has evolved from medical chemists focusing on drug target or pathway in mind and league of elaborative chemistry-driven processes to modern generation of high-throughput screening (HTS) libraries that are created by combinatorial chemistry based on few structural distinctions across large drug like scaffolds.
This change was needed because of high attrition rate in pre-clinical and incubation drug development studies because of earlier methods. While the primary task of medicinal chemists has not changed significantly over a period of time, the computational tools and chemicals and perspectives at their clearance or removal have advanced extensively.
The various tools of medicinal chemistry are in silico modeling, structure-based drug design (SBDD), comparative molecular field analysis (CoMFA) or 3D QSAR method. In particular the fragment-based drug design promisingly stands out because of substantial improvements in research and productivity. One of the primary challenges of drug discovery is to design a robust drug that is both safe and effective in a wide range of population. The various drug designing types are structure-based drug design, natural products-based drug design, fragment-based drug design, diversity oriented synthesis and chemogenomics.
Medicinal Chemistry for Drug Discovery Market: Trends
Due to modern technology an alternative approach to the large combichem libraries (10,000 plus molecules) is available, these are smaller focused arrays known as chemogenetic arrays that assists for confining of particular pharmacophore model for specific family to target but considering ADME and drug-like properties. The compound arrays must be synthetically feasible and to minimize the attrition rate in preclinical testing, must also consist of specific properties regarding adsorption, distribution, metabolism, elimination and toxicity (ADMET).
During this process the ADMET constraints established from information mining, in vitro and in vivo studies are often compiled into computational packages to enable chemists to predict the drug-likeliness of a compound.
The recent market trends observed with medicinal chemistry operations are outsourced by most of the pharmaceutical companies because this helps the companies to pace up the research process making it time and cost efficient. The outsourcing trend observed from the North American and European pharmaceutical companies to the companies of developing companies like India, China and Others from Asian continent.
Medicinal Chemistry for Drug Discovery Market: Opportunities and Competitive Dynamics
The mightiest challenge in this industry is to reduce the number of drugs that fail in pre-clinical stages, as this facilitates the manufacturer to enter the market with a high priced drug. But since the ADME profiling used in silico and cellular approaches have successfully reduced the attrition rate. According to industry experts currently structure-based drug design has high acceptance followed by fragment-based variation, natural products, while diversity oriented synthesis and chemogenomics have negligible market shares. The top five active therapeutic research areas are cancer, infections, neurological, gastrointestinal, endocrine and cardiovascular.
Drug discovery is expected to be largely practiced at small niche biopharmaceutical companies around the world in the U.K., U.S., Western Europe, Eastern Europe, China, India, Brazil, South Africa and Mexico as investments, time and risks are comparatively less in this operations model than the traditional. Overall the medicinal chemistry has improved all these years with all updated technologies and methodologies.
The importance of small and medium scaled companies will increase in this market as it will reduce the time and cost for a big pharmaceutical company. Hence, in drug discovery medicinal chemistry plays important role but still the accuracy and precision of the study needs to be improved to achieve minimum rejections in the preclinical studies.
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North America (U.S. and Canada)
Latin America (Mexico, Brazil, Peru, Chile, and others)
Western Europe (Germany, U.K., France, Spain, Italy, Nordic countries, Belgium, Netherlands, Luxembourg)
Eastern Europe (Poland, Russia)
Asia Pacific (China, India, Japan, ASEAN, Australia and New Zealand)
Middle East and Africa (GCC, Southern Africa, North Africa)
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Important changes in market dynamics
Market segmentation up to the second or third level
Historical, current, and projected size of the market from the standpoint of both value and volume
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Market shares and strategies of key players
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Pharmaceutical market in Rome, Italy
Past Conference Report
Medicinal Chemistry 2019
Conference Series LLC Ltd sincerely thanks all of our wonderful Speakers, Conference Attendees and Collaborators; Medicinal Chemistry 2019 Conference was our best ever!
14th World Congress on Medicinal Chemistry and Drug Design June10-11, 2019 Edinburgh, Scotland hosted by Conference Series LLC Ltd was held during June10-11, 2019 Edinburgh, Scotland at Holiday with the theme “A decade of Development on Medicinal Chemistry and Evolution of Fragment-based Drug Design” which got splendid response. With the support and guidance of Organizing Committee Members and Editorial Board Members in the fields of Medicinal chemistry and Mass Spectrometry and astonishing presentations of all participants this prominent event became more impressive.
Conference Series LLC Ltd would like to convey a great appreciation to following eminent people, honourable guests and Keynote speakers.
- James K Bashkin, University of Missouri-St. Louis, USA
- Daniel P Becker, Loyola University Chicago, USA
- Orazio Nicolotti, University of Bari, Italy
- Karol S Bruzik, University of Illinois, USA
- Letizia Giampietro, University “G. d’Annunzio”, Italy
- Daniela Andrei, Dominican University, USA
- Alex R Khomutov, Russian Academy of Sciences, Russia
- Alessandra Ammazzalorso, University of Chieti, Italy
- Mary Anti Chama, University of Ghana, Ghana
Conference Series LLC Ltd extends its gratitude towards Poster Judge Daniela Andrei, Dominican University, USA. We also congratulate our Best Poster awardees for their outstanding performances in the field of Medicinal Chemistry and appreciate all the participants who had put their efforts in poster presentations and sincerely wish them success in future endeavours.
Medicinal Chemistry 2019 Organizing Committee would like to thank the Moderator of the conference Mary Anti Chama, University of Ghana, Ghana who contributed a lot for the smooth functioning of this event.
Conference Series LLC Ltd also took privilege to felicitate the Keynote Speakers, Organizing Committee Members, Chairs and Co-chairs who supported this event.
With sustainable excitement for grand success of Medicinal Chemistry 2019, Conference Series LLC Ltd is glad to announce next annual meeting
15th World Congress on Medicinal Chemistry and Drug Design to be held during June 22-23, 2020 in Rome, Italy We hope your favourable support will make next annual also one more grand success event.