Market Analysis - Nephrologists 2018
Morality rate in kidney diseases
According to the recent statistics the 18th leading death cause of Italy is kidney diseases. The morality rate in Italy for kidney diseases is 5.47 In the world, every year at least 2.3 million people may have died because of kidney failure. In 2030 number of people receiving dialysis or kidney transplantation set to more than double to over 5 million. In USA every 1 in 3 adults is currently at risk for developing kidney diseases. The 9th leading cause of deaths in USA is kidney disease. In USA 6 lakh deaths are due to kidney diseases. It is being acknowledged that throughout USA more than 17,105 kidney transplantations took place in 2014 alone. In 2015, 11,570 came from deceased donors and 5,535 came from living donors. Every day 12 people die while waiting for a life-saving kidney transplant. For every 14 minutes an individual is added to the renal transplant list. In 2014, 4,270 patients died due to increasing the lag time for a kidney transplant. Another, 3,617 people became too sick to take delivery of kidney transplant. Medical Expenditures for individual patient per year with kidney disease increase from $15,000 in stage 3 to $28,000 in stage 4 to more than $ 70,000 in stage 5. Every year, Medicare spent nearly $ 28.6 billion to treat people with kidney failure. National kidney Foundation has provided more than $100 million for research. Annually US spent $ 41 billion or 17% of their Medicare budget on people with kidney diseases.
Nephrology scope of practice has undergone profound changes in the past decade. This evolution is largely due to:
• The overall prevalence of CKD in the general population is approximately 14%.
• High blood pressure and diabetes are the main causes of CKD. Almost half of individuals with CKD also have diabetes and/or self-reported cardiovascular disease (CVD).
• More than 661,000 Americans have kidney failure. Of these, 468,000 individuals are on dialysis, and roughly 193,000 live with a functioning kidney transplant.
• Kidney disease often has no symptoms in its early stages and can go undetected until it is very advanced. (For this reason, kidney disease is often referred to as a “silent disease.”)
• The adjusted incidence rate of ESRD in the United States rose sharply in the 1980s and 1990s, levelled off in the early 2000’s, and has declined slightly since its peak in 2006.
• Compared to Caucasians, ESRD prevalence is about 3.7 times greater in African Americans, 1.4 times greater in Native Americans, and 1.5 times greater in Asian Americans.
• The overall prevalence of CKD increased from 12% to 14% between 1988 and 1994 and from 1999 to 2004 but has remained relatively stable since 2004. The largest increase occurred in people with Stage 3 CKD, from 4.5% to 6.0% since 1999.
• Women (15.93%) are more likely to have stages 1 to 4 CKD than men (13.52%).
Age-Adjusted Prevalence of CKD Stages 1-4 by Gender 1999-2015
African Americans (17.01%) and Mexican Americans (15.29%) are more likely to have CKD than Caucasians (13.99%).
Age-Adjusted Prevalence of CKD Stages 1-4 by Race/Ethnicity 1999-2015
• CKD often occurs in the context of multiple comorbidities and has been termed a disease multiplier. Almost half of individuals with CKD also have diabetes and self-reported CVD.
Distribution of NHANES participants with diabetes, self-reported cardiovascular disease, and single-sample markers of CKD, 2007-2015
Abbreviations: CKD- Chronic Kidney Disease; CVD- Cardiovascular Disease; DM- Diabetes Mellitus
Acute Kidney Injury (AKI)
· In 2015, the unadjusted rate of AKI hospitalizations in the Medicare population fell by 4.9%. This decrease was observed across all age and race groups.
· For Medicare patients ages 66 and older with an AKI hospitalization in 2013, the cumulative probability of a recurrent AKI hospitalization within 2 years was 48%.
· Among Medicare patients ages 66 and older with a first AKI hospitalization, the in-hospital mortality rate in 2015 was 9.5% (or 14.4% when including discharge to hospice), and less than half of all patients were discharged to their home.
Hospital discharge status of first AKI hospitalization for Medicare patients aged 66+, 2015
Each year, kidney disease kills more people than breast or prostate cancer. In 2013, more than 47,000 Americans died from kidney disease. In order to accommodate the heterogenic CKD patient population and the wide variety of practice settings, the nephrologist must be prepared to serve as the CKD patient’s primary care provider and/or subspecialty consultant. The use of collaborative practice models in CKD care is essential to meet the needs of this rapidly expanding patient population.
Global burden of nephrology mortality is increasing drastically every year. According to WHO 10% of the population worldwide is affected by kidney diseases and approximately 65 million die each year. Kidney disease was ranked 16th in the list of causes of total number of deaths. Over 2 million people worldwide currently receive treatment with dialysis or a kidney transplant to stay alive. Of the 2 million people who receive treatment for kidney failure, the majority are treated in only five countries – the United States, Japan, Germany, Brazil, and Italy. Reflecting this imperative, we believe that professionally-oriented education in to cure Renal diseases is essential in the training of clinicians and clinical academics who will provide the future leadership in this key area for global health. Nephrologists 2018 aims to bring together leading academic scientists, researchers and research scholars to exchange and share their experiences and research results about all aspects of Nephrology. It also provides the chance for researchers, practitioners and educators to present and discuss the most recent innovations, trends, and concerns, practical challenges encountered and the solutions adopted in the fields of Neonatology and Perinatology.
Nephrologists 2018 is an international platform for presenting research about diagnosis, prevention and management of nephrology diseases, exchanging ideas about it and thus, contributes to the dissemination of knowledge in Nephrology for the benefit of both the academia and business. This event brings together Nephrologists, nephrology scientists and all the eminent researchers and experts in the field of Nephrology and Nephrology drugs to explore the advancements in the Nephrology. We bring together industrial executives, Nephrology Pharma and Health care sectors making the conference a perfect platform to network, share views and knowledge through interactive discussions.
Why it’s in Rome, Italy
Rome is a city and special commune in Italy. Rome is the capital of Italy and also of the homonymous province and of the region of Lazio. With 2.9 million residents in 1,285.3 km2 (496.1sq mi), it is also the country’s largest and most populated commune and fourth-most populous city in the European Union by population within city limits. The urban area of Rome extends beyond the administrative city limits with a population of around 4.2 million. Between 3.2 and 4.2 million people live in Rome metropolitan area. The city is located in the central-western portion of the Italian Peninsula, within Lazio along the shores of the Timber. Rome is the only city in the world to contain in its interior a whole state; the enclave of Vatican City. Rome has a status of the global city. Rome was the 11th-most-visited city in the world, 3rd most visited in the European Union, and the most popular tourist attraction in Italy. The city is one of Europe’s and the world’s most successful city “brands”, both in terms of reputation and assets.
Its historic centre is listed by UNESCO as a World Heritage Site. Monuments and museums such as the Vatican Museums and the Colosseum are among the world’s most visited tourist destinations with both locations receiving millions of tourists a year. Rome hosted the 1960 Summer Olympics. Although associated today only with Latin, ancient Rome was in fact multilingual. In highest antiquity Sabine tribes shared the area of what is today Rome with Latin tribes. The Sabine language was one of the Italic group of ancient Italian languages, along with Etruscan, which would have been the main language of the last three kings who ruled the city till the founding of the Republic in 509 BC. Urganilla, or Plautia Urgulanilla, wife of Emperor Claudius, is thought to have been a speaker of Etruscan many centuries after this date, according to Suetonius’ entry on Claudius. However Latin, in various evolving forms, was the main language of classical Rome, but as the city had immigrants, slaves, residents, ambassadors from many parts of the world it was also multilingual.
Members Associated with Nephrology Research
· Pediatric Nephrology
· Fellows or postdoctoral students
· Nephrology Academicians
· Students pursuing an MD or PhD
· Young research scientists
· Business delegates
Hospitals Associated with Nephrology Research
· Azienda Ospedaliero Universitaria Santa Maria della Misericordia
· Giannina Gaslini Children's Hospital
· Humanitas Gavazzeni
· Azienda Ospedaliero-Universitaria Ospedale Cattinara
· Istituto Mediterraneo per i Trapianti e le Terapie ad Alta Specializzazione
· Klinik Hirslanden, Zurich
· Klinik Im Park, Zurich
· Health Centre Bad Ragaz
· Klinik Pyramide Am See
· Klinik Beau-Site, Berne
· Hirslanden Clinique La Colline
· Lucerne Health
· Salem-Spital, Berne
· Hirslanden Klinik Aarau
· J.W. Goethe University Hospital
· Mayo Clinic
· Cleveland Clinic
· New York-Presbyterian University Hospital of Columbia and Cornell
· UCSF Medical centre
· Brigham and Women's Hospital
· Johns Hopkins Hospital
· Massachusetts General Hospital
· UCLA Medical centre
· Duke University Hospital
· Vanderbilt University Medical centre
Societies Associated with Nephrology Research
· Italian Society of Nephrology
· Danish Society of Nephrology
· Swedish Society of Nephrology
· British Association of Pediatric Nephrol ogy
· French Society of Nephrology
· Polish Society of Nephrology
· Albanian Society of Nephrology
· Belgian Society of Nephrology
· Austrian Society of Nephrology
· German Society of Nephrology
· The Renal Association (UK)
· International Society of Nephrology (ISN) Gateway
· American Society of Nephrology
· The Philippine Society of Nephrology
· Canadian society of nephrology
· Kidney Disease Association
· The National Kidney Foundation
· Chronic Kidney Disease - World Kidney Day
· Clinical Journal of the American Society of Nephrology
· Indian society of nephrology
· Renal association
· The Asian Pacific Society of Nephrology
· Emirates medical association on nephrology society
· Lebanese Society of Nephrology and Hypertension.
Industries Associated with Nephrology Research
· Svenska Cellulosa Aktiebolaget SCA
· Fresenius Medical Care AG & Co. KGaA
· Baxter International Inc.
· Hartmann Group
· ONTEX International N.V.
· First Quality Enterprises, Inc.
· B. Braun Melsungen AG
· Astra Tech Inc.
· Kimberly-Clark Corporation
· Covidien plc
· Bellco Srl
· C. R. Bard, Inc.
· Siemens Healthcare
· EDAP TMS S.A.
· Bellco Srl
· Kaneka Pharma Company
· NxStage Medical, Inc.
· Storz Medical AG
· Siemens Healthcare
· EDAP TMS S.A
· Dornier MedTech GmbH
· Nikkiso CO., LTD.
· Teleflex Incorporated
· Medline Industries, Inc.
· Asahi Kasei Corporation
· Baxter International Inc.
· DaVita HealthCare Partners Inc.
· Keryx Biopharmaceuticals, Inc.
· Mallinckrodt Pharmaceuticals
· Anthem Biopharma
· Janssen Biotech,inc
Universities Associated with Nephrology Research
· Marche Polytechnic University
· Università degli studi di Bari Aldo Moro
· University of Bologna
· University of Molise
· University of Chieti
· University of Ferrara
· University of Foggia
· University of Oxford
· University of Cambridge
· Imperial College London
· University College London
· University of Manchester
· University of Barcelona
· University of Glasgow
· University of Oslo
· Stanford University
· University of Michigan
· Yale school of medicine
· University of Washington
· University of Wisconsin
· Budapest Nephrology School
Market Value on Nephrology Research
According to the recent statistics the 18th leading death cause of Italy is kidney diseases. The morality rate in Italy for kidney diseases is 5.47 In the world, every year at least 2.3 million people may have died because of kidney failure. The 9th leading cause of deaths in USA is kidney disease. It is being acknowledged that throughout USA more than 17,105 kidney transplantations took place in 2014 alone. In 2015, 11,570 came from deceased donors and 5,535 came from living donors. Every day 12 people die while waiting for a life-saving kidney transplant. For every 14 minutes an individual is added to the renal transplant list. In 2014, 4,270 patients died due to increasing the lag time for a kidney transplant. Another, 3,617 people became too sick to take delivery of kidney transplant
According to recent statistics report, nearly 26 million adults apart from young and old aged people are suffering from Chronic Kidney Disease complaints and millions of others are at increased risk. Medical Expenditures per patient per year with kidney disease increase from $15,000 in stage 3 to $28,000 in stage 4 to more than $70,000 in stage 5. Every year Medicare spent nearly $28.6 billion to treat people with kidney failure. National kidney Foundation has provided more than $100 million for research. Annually US spent $41 billion or 17% of their Medicare budget on people with kidney diseases. The numbers of Kidney transplantations are seemingly very high and in the year of 2013 alone, there are around 15000 kidney transplantations. Being one of the major fields of Internal Medicine, Nephrological research received a funding of more than 5 billion dollars annually across the globe. Nearly $ 560 million is being funded on Kidney diseases alone per year due to the rapid increase for the risk of renal disorders.
Market Growth of Nephrology Research in the last and upcoming years
In 2015, the market value for nephrology at USD 16.7 billion, and it is expected to reach an estimated value of USD 23.2 billion in 2021, growing at a CAGR of 6.4% from 2012 to 2018. According to WHO more than 190 million patients suffering from chronic renal failure undergo renal dialysis. In 2011, total Medicare spending was $549.1 billion, and of that, costs for kidney failure were $34.3 billion, or 6.2% of the total Medicare budget. Annually US spent $41 billion or 17% of their Medicare budget on people with kidney diseases. Approximately coming 5 years it is increased to $52 billion for kidney diseases Approximately 17,000 kidney transplants are performed annually, yet the American waiting list for lifesaving kidney transplants includes 95,000 individuals.
Products manufactured by the industry
· Auryxia (Ferric citrate); Keryx Biopharma
· Harvoni (ledipasvir and sofosbuvir); Gilead
· Viekira Pak (ombitasvir, paritaprevir, ritonavir and dasabuvir) tablets; Abbvie
· Procysbi (cysteamine bitartrate); Raptor Pharmaceuticals
· Injectafer (ferric carboxymaltose injection); Luitpold Pharmaceuticals
· Afinitor (everolimus); Novartis
· Inlyta (axitinib); Pfizer
· Myrbetriq (mirabegron)
· Omontys (peginesatide); Affymax
· Stendra (avanafil); Vivus
· Stivarga (regorafenib); Bayer HealthCare Pharmaceuticals
· Voraxaze (glucarpidase); BTG International
· Anturol (oxybutynin) Gel; Antares Pharma
· Nulojix (belatacept); Bristol-Myers Squibb
· Soliris (eculizumab); Alexion
· Aranesp® — U.S
· Sensipar® — U.S
· Catheter Guidewires
· Single Lumen Femoral Catheter
· Haemodialysis Double Lumen Catheter
· Haemodialysis Triple Lumen Catheter Kit
· Haemodialysis Catheter Kit Double Lumen
· Transducer Protector
· Fistula Needle
· Biopsy Needle Manual
· Hand Control Pencil
· Nitinol core wire
· Dialysis Catheter
· Disposable Fistula Needle
· Pediatric Protector
· Pediatric Transducer
· Femoral Catheter
· Haemodialysis Catheter
· AV Fistula Needle
· Biopsy Gun
Fund Allotment to Nephrology Research
· Feeding America- $1.86 billion- up 22.8% from a year earlier.
· Salvation Army - $2.08 billion- year-to-year 10.3% increase
· Predictive factors of long-term dysfunction and renal graft loss- 5.500 €- Source: Centro Hospitalar do Porto and UMIB/FCT
· American Kidney Fund- $213 M
· Simultaneous kidney-pancreas transplantation- 24.000 €- Source: Department of Nephrology from Centro Hospitalar do Porto
· Nephropatic hereditary amyloidosis- Funding: 2.000 €- Source: Portuguese Society of Nephrology and Funding: 2.100 €. Source: UMIB/FCT
· Uremia and functional-structural peritoneal membrane changes- Funding: 25.000 €. Source: Portuguese Society of Nephrology.
· Salvation Army - $2.08 billion- year-to-year 10.3% increase
· European Living Donor Psychosocial Follow-up- Funding: 1.4 €.
· Task Force for Global Health- $1.57 billion- 5.2% drop in donations.
· Metabolic changes in peritoneal dialysis- Funding: 2.600 €. Source: UMIB/FCT.
Statistics of Physicians, Researchers and Academicians working on Nephrology
· Total nephrologists-8567
· Students-1, 25,075
· Total nephrologists-55,545